GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs6951245 | 1 | rs1997243 | chr7:1083777 | ZFAND2A | chr7:1192544-1199855:- | -0.39 | -4.55 | 7.23E-6 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs1577917 | 1 | rs1999852 | chr6:86705738 | SNHG5 | chr6:86386726-86388451:- | -0.52 | -9.19 | 2.57E-18 | Response to antipsychotic treatment |
| BLCA | cis | rs7112513 | 1 | rs2000614 | chr11:116915742 | PCSK7 | chr11:117075789-117102811:- | -0.39 | -5.09 | 5.59E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs2000615 | chr11:116915819 | PCSK7 | chr11:117075789-117102811:- | -0.39 | -5.05 | 7.01E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7112513 | 1 | rs2000616 | chr11:116916529 | PCSK7 | chr11:117075789-117102811:- | -0.39 | -5.09 | 5.59E-7 | Protein quantitative trait loci |
| BLCA | cis | rs7714584 | 1 | rs2004711 | chr5:150225068 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.26 | 2.42E-7 | Crohn's disease |
| BLCA | cis | rs4237643 | 1 | rs2006751 | chr11:43670501 | HSD17B12 | chr11:43702143-43878160:+ | -0.42 | -6.9 | 2.22E-11 | Forced vital capacity |
| BLCA | cis | rs2143950 | 1 | rs2010648 | chr14:35604892 | PPP2R3C | chr14:35554679-35591679:- | 0.25 | 4.13 | 4.45E-5 | Atopic dermatitis |
| BLCA | cis | rs9457247 | 1 | rs2013815 | chr6:167373812 | RNASET2 | chr6:167343008-167412795:- | 0.22 | 4.7 | 3.57E-6 | Crohn's disease |
| BLCA | cis | rs7224737 | 1 | rs2014521 | chr17:40283413 | DHX58 | chr17:40253422-40264751:- | -0.25 | -4.56 | 6.82E-6 | Fibrinogen levels |
| BLCA | cis | rs6715284 | 1 | rs2019097 | chr2:202193463 | PPIL3 | chr2:201735680-201753999:- | -0.42 | -4.58 | 6.39E-6 | Rheumatoid arthritis |
| BLCA | cis | rs2028299 | 1 | rs2028299 | chr15:90374257 | AP3S2 | chr15:90373832-90456222:- | -0.7 | -10.63 | 2.6E-23 | Type 2 diabetes |
| BLCA | cis | rs9876781 | 1 | rs2045554 | chr3:48494542 | TREX1 | chr3:48501186-48509043:+ | 0.2 | 4.04 | 6.42E-5 | Longevity |
| BLCA | cis | rs9309473 | 1 | rs2056486 | chr2:73717567 | ALMS1P | chr2:73872046-73912692:+ | 0.4 | 5.97 | 5.32E-9 | Metabolite levels |
| BLCA | cis | rs2404602 | 1 | rs2056544 | chr15:76826003 | SCAPER | chr15:76640529-77197744:- | -0.2 | -4.4 | 1.43E-5 | Blood metabolite levels |